Vitamin D status and its relationship with bone mineral density in healthy Asian Indians

• Published in: Osteoporosis international Vol. 15; no. 1; pp. 56 - 61
• Main Authors: Arya, Vivek, Bhambri, Rajiv, Godbole, Madan M., Mithal, Ambrish
• Format: Journal Article
• Language: English
• Published: London Springer 01.01.2004; Springer Nature B.V
• Subjects: Absorptiometry, Photon - methods; Adult; Biological and medical sciences; Bone density; Bone Density - physiology; Calcitriol - blood; Calcium, Dietary - administration & dosage; Diseases of the osteoarticular system; Endocrinology; Female; Humans; Immunoradiometric Assay - methods; India; Male; Medical sciences; Middle Aged; Osteoporosis; Osteoporosis. Osteomalacia. Paget disease; Parathyroid Hormone - blood; Radioimmunoassay - methods; Solvent extraction processes; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - diagnosis; Vitamin deficiency; Indian subcontinent; Human; Status; Critically ill; Health staff; Diseases of the osteoarticular system; Nutrition disorder; Health care staff; Vitamin deficiency; Sunshine; X ray; Concentration; Assay; Osteoporosis; Parathormone; Synthesis; Vitamin D; Parathyroid hormone; Radioimmunoassay; Indian; Serum; Bone mineral density; Skin
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-003-1491-3

Synthesis of vitamin D takes place in the skin under the effect of sunlight. The Indian subcontinent is situated between 8.4 degrees N and 37.6 degrees N latitudes and has adequate sunshine throughout the year. Thus, it has been presumed that Indians are vitamin D sufficient. We measured serum 25-hydroxy vitamin D [25(OH)D] ( n=92) and 1,25-dihydroxy vitamin D [1, 25(OH)(2)D] ( n=65) levels in healthy hospital staff, using (125)I radioimmunoassay. Serum intact parathyroid hormone (PTH) concentration was estimated by immunoradiometric assay. Bone mineral density was estimated using a dual energy X-ray absorptiometer (Hologic QDR 4500A). Using a serum 25(OH)D level of 15 ng/ml as a cutoff, 66.3% (61/92) of the subjects were found to be vitamin D deficient. Of these, 20.6% (19/92) subjects had severe vitamin D deficiency (<5 ng/ml), 27.2% (25/92) had moderate vitamin D deficiency (5-9.9 ng/ml), while 18.5% (17/92) had mild vitamin D deficiency (10-14.9 ng/ml). When a serum 25(OH)D level of 20 ng/ml was used as a cutoff, 78.3% subjects were diagnosed to be vitamin D deficient/insufficient. The serum 1,25(OH)(2)D level was within the normal range (40.6+/-20.1 pg/ml; mean +/- SD). Mean (+/-SD) serum intact PTH, estimated in a limited number of subjects (n=15), was 72.3 (+/-21.0) pg/ml (range 36-100 pg/ml). There was a significant correlation between daily sun exposure and 25(OH)D levels (r=0.731, P<0.001). The serum 25(OH)D level correlated with BMD at the femoral neck and Ward's triangle (r=0.50, P=0.020 and r=0.46, P=0.037, respectively). Our findings show that vitamin D deficiency is common in urban north Indian hospital staff. The possible reasons include inadequate sunlight exposure and skin pigmentation in Indians. The serum 1,25(OH)(2)D level is not a good indicator of vitamin D deficiency. A low serum 25(OH)D level is possibly one of the reasons for lower bone mineral density among Indians.