Antihyperlipidemic effect of diosmin: A citrus flavonoid on lipid metabolism in experimental diabetic rats

The present study was hypothesized to evaluated the antihyperlipidemic effect of diosmin (DS) on lipid metabolism in experimental diabetic rats. Diabetes was induced male albino Wistar rats by intraperitoneal administration of streptozotocin (STZ) (45 mg/kg b.w.) 15 min after the ip administration o...

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Bibliographic Details
Published inJournal of functional foods Vol. 5; no. 1; pp. 484 - 492
Main Authors Srinivasan, Subramani, Pari, Leelavinothan
Format Journal Article
LanguageEnglish
Published Elsevier 01.01.2013
Subjects
Cholesterol
Diosmin
Lipoproteins
Streptozotocin
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Summary:The present study was hypothesized to evaluated the antihyperlipidemic effect of diosmin (DS) on lipid metabolism in experimental diabetic rats. Diabetes was induced male albino Wistar rats by intraperitoneal administration of streptozotocin (STZ) (45 mg/kg b.w.) 15 min after the ip administration of nicotinamide (NA) (110 mg/kg b.w.). DS were administered to diabetic rats intragastrically at 100 mg/kg b.w. for 45 days. The levels of plasma and tissue lipids (cholesterol, triglycerides) (TGs), free fatty acids (FFAs) and phospholipids (PLs), low density, very low-density lipoproteins (LDL and VLDL), and high-density-cholesterol (HDL-C) were measured. The activities of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) were assayed. The levels of plasma and tissue lipids decreased with significant increase in HDL-C levels. The altered activities of lipid metabolic enzymes were restored to near normal. The present findings suggest that DS can potentially ameliorate lipid abnormalities in experimental diabetes.
ISSN:1756-4646
DOI:10.1016/j.jff.2012.12.004