High resolution scanning electron microscopy of the intracellular surface of intercalated disks in human heart

The three-dimensional architecture of human cardiac intercalated disks was examined by high resolution scanning electron microscopy of osmium-macerated specimens. This methodology permits viewing of in situ intercalated disks from a vantage point inside individual cardiomyocytes. The erose nature of...

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Bibliographic Details
Published inTissue & cell Vol. 38; no. 6; pp. 417 - 420
Main Authors Tandler, B., Riva, L., Loy, F., Conti, G., Isola, R.
Format Journal Article
LanguageEnglish
Published Scotland Elsevier Ltd 01.12.2006
Subjects
Adherens Junctions - ultrastructure
Adolescent
Adult
Desmosomes
Desmosomes - ultrastructure
Fasciae adherentes
Gap junctions
HRSEM
Human heart
Humans
Intercalated disks
Intercellular Junctions - ultrastructure
Microscopy, Electron, Scanning
Myocardium - ultrastructure
Myocytes, Cardiac - ultrastructure
Myofibrils - ultrastructure
Fasciae adherentes
Desmosomes
Human heart
HRSEM
Gap junctions
Intercalated disks
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Summary:The three-dimensional architecture of human cardiac intercalated disks was examined by high resolution scanning electron microscopy of osmium-macerated specimens. This methodology permits viewing of in situ intercalated disks from a vantage point inside individual cardiomyocytes. The erose nature of these structures was rendered in stark relief. Areas covered with clusters of particles were present on some membranous projections—these may represent a combination of desmosomes and fasciae adherentes. On the other hand, areas devoid of particles may correspond to gap junctions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2006.09.001