Detection Of Multiple Human Papillomavirus Types In Condylomata Acuminata From Immunosuppressed Patients

Using the hybrid capture method, condylomata acuminata from healthy patients (controls) and patients with altered cell-mediated immunity were analyzed for multiple human papillomavirus (HPV) DNA: 82.9% and 38.0% oflesions from 41 controls and 21 patients, respectively, were HPV DNA-positive only wit...

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Published inThe Journal of infectious diseases Vol. 170; no. 4; pp. 759 - 765
Main Authors Brown, Darron R., Bryan, Janine T., Cramer, Harvey, Katz, Barry P., Handy, Victoria, Fife, Kenneth H.
Format Journal Article
LanguageEnglish
Published United States The University of Chicago Press 01.10.1994
University of Chicago Press
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Abstract Using the hybrid capture method, condylomata acuminata from healthy patients (controls) and patients with altered cell-mediated immunity were analyzed for multiple human papillomavirus (HPV) DNA: 82.9% and 38.0% oflesions from 41 controls and 21 patients, respectively, were HPV DNA-positive only with probes for low-risk HPV types (P = .00035). Using probes for both low- and high-risk HPV types, 16.3% and 52.3% of lesions from 43 controls and 21 patients, respectively, were positive for both probes (P = .0038). Evidence of multiple HPV types was also found by Southern blot and in situ hybridization studies. The mean HPV copy number detected by either probe did not differ significantly among patient groups. Using sensitive techniques, such as hybrid capture, multiple HPV types, including those associated with genital malignancy, can be detected in condylomata acuminata. Serial biopsies demonstrate the dynamic nature of genital HPV infection and that changes in the predominant HPV types may be reflected in tissue pathology.
AbstractList Using the hybrid capture method, condylomata acuminata from healthy patients (controls) and patients with altered cell-mediated immunity were analyzed for multiple human papillomavirus (HPV) DNA: 82.9% and 38.0% of lesions from 41 controls and 21 patients, respectively, were HPV DNA-positive only with probes for low-risk HPV types (P = .00035). Using probes for both lowand high-risk HPV types, 16.3% and 52.3% of lesions from 43 controls and 21 patients, respectively, were positive for both probes (P = .0038). Evidence of multiple HPV types was also found by Southern blot and in situ hybridization studies. The mean HPV copy number detected by either probe did not differ significantly among patient groups. Using sensitive techniques, such as hybrid capture, multiple HPV types, including those associated with genital malignancy, can be detected in condylomata acuminata. Serial biopsies demonstrate the dynamic nature of genital HPV infection and that changes in the predominant HPV types may be reflected in tissue pathology.
Using the hybrid capture method, condylomata acuminata from healthy patients (controls) and patients with altered cell-mediated immunity were analyzed for multiple human papillomavirus (HPV) DNA: 82.9% and 38.0% of lesions from 41 controls and 21 patients, respectively, were HPV DNA-positive only with probes for low-risk HPV types (P = .00035). Using probes for both low- and high-risk HPV types, 16.3% and 52.3% of lesions from 43 controls and 21 patients, respectively, were positive for both probes (P = .0038). Evidence of multiple HPV types was also found by Southern blot and in situ hybridization studies. The mean HPV copy number detected by either probe did not differ significantly among patient groups. Using sensitive techniques, such as hybrid capture, multiple HPV types, including those associated with genital malignancy, can be detected in condylomata acuminata. Serial biopsies demonstrate the dynamic nature of genital HPV infection and that changes in the predominant HPV types may be reflected in tissue pathology.
Using the hybrid capture method, condylomata acuminata from healthy patients (controls) and patients with altered cell-mediated immunity were analyzed for multiple human papillomavirus (HPV) DNA: 82.9% and 38.0% oflesions from 41 controls and 21 patients, respectively, were HPV DNA-positive only with probes for low-risk HPV types (P = .00035). Using probes for both low- and high-risk HPV types, 16.3% and 52.3% of lesions from 43 controls and 21 patients, respectively, were positive for both probes (P = .0038). Evidence of multiple HPV types was also found by Southern blot and in situ hybridization studies. The mean HPV copy number detected by either probe did not differ significantly among patient groups. Using sensitive techniques, such as hybrid capture, multiple HPV types, including those associated with genital malignancy, can be detected in condylomata acuminata. Serial biopsies demonstrate the dynamic nature of genital HPV infection and that changes in the predominant HPV types may be reflected in tissue pathology.
Author Cramer, Harvey
Bryan, Janine T.
Fife, Kenneth H.
Katz, Barry P.
Handy, Victoria
Brown, Darron R.
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Notes Reprints or correspondence: Dr. Darron R. Brown. Division of Infectious Diseases. Indiana University School of Medicine. Emerson Hall. Rm. 435. 545 Barnhill Dr.. Indianapolis. IN 46202–5124.
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SubjectTerms AIDS/HIV
Biopsies
Biopsy
Blotting, Southern
Condylomata acuminata
Condylomata Acuminata - pathology
Condylomata Acuminata - virology
DNA
DNA probes
DNA, Viral - isolation & purification
Female
Genitalia
HIV Seropositivity - immunology
HIV Seropositivity - virology
Human papillomavirus 16
Humans
Hybridity
Immunity, Cellular
Immunosuppression
In Situ Hybridization
Infections
Lesions
Major Article
Papillomaviridae - isolation & purification
Papillomaviridae - pathogenicity
Papillomavirus Infections - epidemiology
Reference Values
Risk Factors
Tumor Virus Infections - epidemiology
Title Detection Of Multiple Human Papillomavirus Types In Condylomata Acuminata From Immunosuppressed Patients
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