Genetic equidistance at nucleotide level

• Published in: Genomics (San Diego, Calif.) Vol. 109; no. 3-4; pp. 192 - 195
• Main Authors: Yuan, Dejian, Huang, Shi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Evolution, Molecular; Fast-evolving sequences; Genetic equidistance phenomenon; Genetic Variation; Humans; Maximum genetic diversity hypothesis; Molecular clock; Neutral theory; Overlap sites; Proteome - chemistry; Proteome - genetics; Sequence Alignment; Sequence Analysis, DNA; Sequence Analysis, Protein; Slow-evolving sequences; Vertebrates - genetics; Genetic equidistance phenomenon; Slow-evolving sequences; Neutral theory; Maximum genetic diversity hypothesis; Molecular clock; Fast-evolving sequences; Overlap sites
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/j.ygeno.2017.03.002

The genetic equidistance phenomenon shows complex taxa to be all approximately equidistant to a less complex species in amino acid percentage identity. The overlooked mystery was re-interpreted by the maximum genetic diversity hypothesis (MGD). Here, we studied 14 proteomes and their coding DNA sequences (CDS) to see if the equidistance phenomenon also holds at the CDS level. We found that the outgroup taxon was equidistant to the two more complex taxa species. When two sister taxa were compared to human as the outgroup, the more complex taxon was closer to human, confirming species complexity to be the primary determinant of MGD. Finally, we found the fraction of overlap sites to be inversely correlated with CDS conservation, indicating saturation to be more common in less conserved DNAs. These results establish the genetic equidistance phenomenon to be universal at the DNA level and provide additional evidence for the MGD theory. •Establish the genetic equidistance phenomenon at the DNA level.•Inverse correlation between the overlap ratio and DNA conservation.•Provide additional evidence for the MGD theory.