To sprout or to split? VEGF, Notch and vascular morphogenesis

Therapeutic angiogenesis is an attractive strategy to treat patients suffering from peripheral or coronary artery disease. VEGF (vascular endothelial growth factor-A) is the fundamental factor controlling vascular growth in both development and postnatal life. The interplay between the VEGF and Notc...

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Bibliographic Details
Published inBiochemical Society transactions Vol. 39; no. 6; p. 1644
Main Authors Gianni-Barrera, Roberto, Trani, Marianna, Reginato, Silvia, Banfi, Andrea
Format Journal Article
LanguageEnglish
Published England 01.12.2011
Subjects
Animals
Blood Vessels - growth & development
Cellular Microenvironment
Humans
Morphogenesis
Neovascularization, Physiologic
Receptors, Notch - metabolism
Vascular Endothelial Growth Factor A - metabolism
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Summary:Therapeutic angiogenesis is an attractive strategy to treat patients suffering from peripheral or coronary artery disease. VEGF (vascular endothelial growth factor-A) is the fundamental factor controlling vascular growth in both development and postnatal life. The interplay between the VEGF and Notch signalling pathway has been recently found to regulate the morphogenic events leading to the growth of new vessels by sprouting. Angiogenesis can also take place by an alternative process, i.e. intussusception or vascular splitting. However, little is known about its role in therapeutic angiogenesis and its molecular regulation. In the present article, we briefly review how VEGF dose determines the induction of normal or aberrant angiogenesis and the molecular regulation of sprouting angiogenesis by Notch signalling, and compare this process with intussusception.
ISSN:1470-8752
DOI:10.1042/bst20110650