Kinetics of interaction of local anesthetics with human serum albumin

We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible...

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Published inBulletin of experimental biology and medicine Vol. 140; no. 3; pp. 315 - 316
Main Authors Galenko-Yaroshevskii, A P, Fistunenko, P N, Dukhanin, A S
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.09.2005
Subjects
Albumin
Anesthetics
Anesthetics, Local - chemistry
Benzimidazoles - chemistry
Bupivacaine
Bupivacaine - chemistry
Human serum albumin
Humans
Isotopes
Kinetics
Lidocaine
Lidocaine - chemistry
Local anesthesia
Local anesthetics
Serum Albumin - chemistry
Tetracaine
Tetracaine - chemistry
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Summary:We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible process; equilibrium was attained within 1.5-4.5 h depending on chemical nature of local anesthetics.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0477-x