Endothelin B receptors targeted by iron oxide nanoparticles functionalized with a specific antibody: toward immunoimaging of brain tumors

In this study, we developed a new bimodal imaging tracer directed against endothelin B receptors to detect brain cancer cells using MRI and to assist tumor surgery with fluorescence imaging. This was achieved by coating the surface of iron oxide nanoparticles with a monoclonal antibody, rendomab-B1,...

Full description

Saved in:
Bibliographic Details
Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 3; no. 15; pp. 2939 - 2942
Main Authors Richard, S, Boucher, M, Herbet, A, Lalatonne, Y, Mériaux, S, Boquet, D, Motte, L
Format Journal Article
LanguageEnglish
Published England 21.04.2015
Subjects
Antibodies
Brain
Imaging
Iron oxides
Nanoparticles
Nanostructure
Receptors
Tumors
Online AccessGet full text

Cover

More Information
Summary:In this study, we developed a new bimodal imaging tracer directed against endothelin B receptors to detect brain cancer cells using MRI and to assist tumor surgery with fluorescence imaging. This was achieved by coating the surface of iron oxide nanoparticles with a monoclonal antibody, rendomab-B1, labeled with a fluorescent dye. Two nanoplatforms were elaborated differing by the average number of antibodies grafted onto the nanoparticle surface. The targeting efficiency of these nanoplatforms was validated in vitro. Contrasting MRI properties were highlighted in vivo, demonstrating nanoparticle circulation in the brain through the vasculature.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2050-750X
2050-7518
DOI:10.1039/c5tb00103j