Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage?

• Published in: Indian journal of medical microbiology Vol. 47; p. 100536
• Main Authors: Çetin, Sinan, Telli, Enes, Şahin, Ahmet Melih, Uğur, Mediha, Aydın, Emsal, Şenel, İlknur, Yetkin, Meltem Arzu
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01.01.2024
• Subjects: Antibiotic; Diarrhea; Gastroenteritis; PCR; Diarrhea; Antibiotic; Gastroenteritis; PCR
• ISSN: 0255-0857; 1998-3646
• DOI: 10.1016/j.ijmmb.2024.100536

We aimed to determine the pathogens detected by the Gastrointestinal (GI) PCR panel in patients with acute gastroenteritis (AGE), the evaluation of antibiotic use in these patients, and the investigation of the role of laboratory parameters in differentiating viral and bacterial etiologies. The demographic characteristics, GI PCR panel results, laboratory investigations, antibiotic usage, and appropriateness of antibiotic treatment were investigated in AGE patients. A total of 175 adult patients with AGE and GI PCR panel results were included in the study. The most common pathogens were EPEC (24.6%) and C. difficile (18.3%). Among the 102 patients receiving antibiotic treatment, 34.3% were evaluated as inappropriate antibiotic use. WBC, CRP, procalcitonin, CRP/albumin ratio, and procalcitonin/albumin ratio were found to be significantly higher in cases with bacterial origin. The utilization of GI PCR panels in AGE patients has revolutionized the field of diagnostics by providing rapid and accurate identification of pathogens. In units without the possibility of GI PCR testing, CRP, procalcitonin, CRP/albumin ratio and procalcitonin/albumin ratio may be useful in the decision of antibiotic treatment.