A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany

• Published in: Journal of hypertension Vol. 27; no. 5; p. 983
• Main Authors: Hoffmann, Katrin, Planitz, Christian, Rüschendorf, Franz, Müller-Myhsok, Bertram, Stassen, Hans H, Lucke, Barbara, Mattheisen, Manuel, Stumvoll, Michael, Bochmann, Rolf, Zschornack, Martin, Wienker, Thomas F, Nürnberg, Peter, Reis, André, Luft, Friedrich C, Lindner, Tom H
• Format: Journal Article
• Language: English
• Published: England 01.05.2009
• Subjects: Adult; Aged; Chromosome Mapping; Chromosomes, Human, Pair 1; Female; Genetic Linkage; Genome-Wide Association Study - methods; Germany; Humans; Hypertension - genetics; Lod Score; Male; Metabolic Syndrome - genetics; Middle Aged; Multigene Family - genetics; Population Groups - genetics

Genome-wide linkage studies and genome-wide association studies have not as yet identified major genes contributing to primary hypertension in the general population. This state-of-affairs suggests considerable heterogeneity with small contributing effects for primary hypertension, or other complex...