A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany

Genome-wide linkage studies and genome-wide association studies have not as yet identified major genes contributing to primary hypertension in the general population. This state-of-affairs suggests considerable heterogeneity with small contributing effects for primary hypertension, or other complex...

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Published inJournal of hypertension Vol. 27; no. 5; p. 983
Main Authors Hoffmann, Katrin, Planitz, Christian, Rüschendorf, Franz, Müller-Myhsok, Bertram, Stassen, Hans H, Lucke, Barbara, Mattheisen, Manuel, Stumvoll, Michael, Bochmann, Rolf, Zschornack, Martin, Wienker, Thomas F, Nürnberg, Peter, Reis, André, Luft, Friedrich C, Lindner, Tom H
Format Journal Article
LanguageEnglish
Published England 01.05.2009
Subjects
Adult
Aged
Chromosome Mapping
Chromosomes, Human, Pair 1
Female
Genetic Linkage
Genome-Wide Association Study - methods
Germany
Humans
Hypertension - genetics
Lod Score
Male
Metabolic Syndrome - genetics
Middle Aged
Multigene Family - genetics
Population Groups - genetics
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Summary:Genome-wide linkage studies and genome-wide association studies have not as yet identified major genes contributing to primary hypertension in the general population. This state-of-affairs suggests considerable heterogeneity with small contributing effects for primary hypertension, or other complex genetic traits, in outbred populations. Isolated populations, as recent data from Iceland and French Canada suggest, could offer a solution to this problem. We studied a Slavic isolate in Germany, the Sorbs, and genotyped 1040 polymorphic microsatellite markers in 87 multigeneration families. Our genome-wide linkage scan revealed a locus on chromosome 1p36.13 at D1S3669-D1S2826 (40.95 cM Marshfield coordinates; logarithm of the odds = 3.45, nominal P = 0.00003) that reached genome-wide significance (P = 0.004), indicating the increased power in isolated populations. The chromosome 1 locus maps to a region in which traits such as diabetes, hyperlipidemia, obesity and BMI cluster. Our results suggest that this locus contributes to the metabolic syndrome, and that further attention in this and other populations is warranted.
ISSN:1473-5598
DOI:10.1097/HJH.0b013e328328123d