Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering

Successful regeneration of weight‐bearing bone defects and critical‐sized cartilage defects remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical and physical properties have been rapidly developed as ideal candidates for bon...

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Bibliographic Details
Published inAdvanced functional materials Vol. 29; no. 36
Main Authors Zhang, Yanbo, Liu, Xiaochen, Zeng, Liangdan, Zhang, Jin, Zuo, Jianlin, Zou, Jun, Ding, Jianxun, Chen, Xuesi
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc 01.09.2019
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Summary:Successful regeneration of weight‐bearing bone defects and critical‐sized cartilage defects remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical and physical properties have been rapidly developed as ideal candidates for bone and cartilage tissue engineering scaffolds. Due to their unique advantages over other materials of high specific‐surface areas, suitable mechanical strength, and tailorable characteristics, scaffolds made of polymer fibers have been increasingly used for the repair of bone and cartilage defects. This Review summarizes the preparation and compositions of polymer fibers, as well as their characteristics. More importantly, the applications of polymer fiber scaffolds with well‐designed structures or unique properties in bone, cartilage, and osteochondral tissue engineering have been comprehensively highlighted. On the whole, such a comprehensive summary affords constructive suggestions for the development of polymer fiber scaffolds in bone and cartilage tissue engineering. The rapid development of polymer fiber scaffolds has attracted increasing attention in tissue engineering recently due to their tailorable, comparable mechanical and biomimetic properties with human tissues. This Review summarizes the preparation, components, and characteristics of polymer fiber scaffolds with well‐designed structures for their applications as bone and cartilage tissue engineering scaffolds and predicts future development.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201903279