Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2＇,1＇：5,1]pyrazolo[4,3-d]pyrimidin-4-one Derivatives

Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.

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Bibliographic Details
Published inChinese journal of chemistry Vol. 25; no. 2; pp. 241 - 245
Main Author 田广辉 夏广新 金薇西 陈新建 赖顺安 韦亚兵 嵇汝运 沈敬山
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.02.2007
WILEY‐VCH Verlag
Wiley
Subjects
Chemistry
Chemistry, Multidisciplinary
PDE5 inhibitor
Physical Sciences
pyridopyrazolopyrimidinone
Science & Technology
sildenafil
化合物
化学活性
合成方法
衍生物
高分子化学
POTENT
SILDENAFIL
PHOSPHODIESTERASE
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Summary:Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.
Bibliography:31-1547/O6
O63
pyridopyrazolopyrimidinone, PDE5 inhibitor, sildenafil
ark:/67375/WNG-CC3MPP7D-0
istex:FB0E3C49BCD95EE32D904161E4C2412C70511E9E
ArticleID:CJOC200790048
Tel./Fax: 0086‐021‐50805891
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.200790048