Silver catalyzed pyridine‐directed acceptorless dehydrogenation of secondary alcohols

• Published in: Journal of the Chinese Chemical Society (Taipei) Vol. 68; no. 2; pp. 245 - 249
• Main Authors: Zhuang, Xin, Tao, Jing, Luo, Zhen, Hong, Chuan‐Ming, Liu, Zheng‐Qiang, Li, Qing‐Hua, Ren, Li‐Qing, Luo, Qun‐Li, Liu, Tang‐Lin
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.02.2021; Wiley; Wiley Subscription Services, Inc
• Subjects: acceptorless dehydrogenation; atom‐economy; Benzyl alcohol; Chemistry; Chemistry, Multidisciplinary; Dehydrogenation; Functional groups; Hydrogen-based energy; Ketones; Physical Sciences; Science & Technology; silver catalyzed; Substrates; SELECTIVE OXIDATION; HYDROGENATION; IRIDIUM; COMPLEXES; CARBONYL-COMPOUNDS; silver catalyzed; OPPENAUER-TYPE OXIDATION; acceptorless dehydrogenation; LESS DEHYDROGENATION; ALLYLIC ALCOHOLS; atom-economy; AEROBIC OXIDATION; CARBOXYLIC-ACIDS
• ISSN: 0009-4536; 2192-6549
• DOI: 10.1002/jccs.202000517

A silver catalyzed pyridine‐directed acceptorless dehydrogenation of secondary benzyl alcohols was developed. This general procedure delivers ketones with high atom‐economy and hydrogen was the sole byproduct. This dehydrogenation reaction has a good functional group tolerance and high efficiency (up to 90% yield and 10,000/1 substrates‐to‐catalyst ratio). Dehydrogenation of alcohols with silver‐silver catalyzed pyridine‐directed acceptorless dehydrogenation of secondary benzyl alcohols was developed. Ketones were offered with high atom‐economy and hydrogen was the sole by‐product.