Short Review on the Synthesis of Thiophene, Pyrazole, and Thiazole Derivatives

The review summarizes the synthesis of different thiophene, pyrazole, and thiazole derivatives by refluxing 9a in ethanol with a catalytic amount of TEA or leaving it in DMF containing potassium carbonate at room temperature overnight to afford the corresponding thiophene derivative 10a. In addition...

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Bibliographic Details
Published inJournal of the Chinese Chemical Society (Taipei) Vol. 65; no. 2; pp. 189 - 204
Main Author Elkanzi, Nadia Ali Ahmed
Format Journal Article
LanguageEnglish
Published Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.02.2018
Wiley Subscription Services, Inc
Subjects
Carbonyl compounds
Carbonyls
Catalysis
Derivatives
Ethanol
Imines
Methylene compound
Potassium carbonate
Pyrazole
Refluxing
Synthesis
Thiazole
Thiophene
Triethylamine
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Summary:The review summarizes the synthesis of different thiophene, pyrazole, and thiazole derivatives by refluxing 9a in ethanol with a catalytic amount of TEA or leaving it in DMF containing potassium carbonate at room temperature overnight to afford the corresponding thiophene derivative 10a. In addition, cyclization of Schiff bases with thioglycollic acid in the presence of a catalytic amount of ZnCl2 yielded novel thiophene derivatives. Condensation of 2‐substituted‐4‐methylythio semi‐carbazides 92 with carbonyl compounds under strong acidic conditions afforded 2‐thiazolines. Also, carboxylic acid reacted with 2‐thioethylamine in the presence of triphenylphosphine and triethylamine to afford 2‐thiazolines 98. Synthesis of thiophene derivatives (10a‐e) and (12a‐e), Furthermore, heating of the intermediate(11a)in ethanol containing a catalytic amount of TEA affords the thiophene derivative (12a).On the other hand, it has been found that (12a‐e)are directly formed by treatment of(6a‐e)with chloroacetonitrile in dimethylformamide and in the presence of potassium carbonate at room temperature over night by pathway(1)
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.201700207