A Palladium-Catalyzed Synthesis of Amidines from Aryl Halides

Tin‐free three‐component coupling: Palladium‐catalyzed coupling between aryl or heteroaryl bromides, primary or secondary amines, and tert‐butyl isocyanide gives high yields of pharmaceutically interesting arylamidines [Eq. (1)]. dppf=1,1′‐bis(diphenylphosphanyl)ferrocene; R1/R2=Bu/H, Ph/H, −(CH2)4−...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 39; no. 22; pp. 4156 - 4158
Main Authors Saluste, C. Gustaf, Whitby, Richard J., Furber, Mark
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 17.11.2000
WILEY‐VCH Verlag GmbH
Wiley
Subjects
amidines
Chemistry
Chemistry, Multidisciplinary
homogeneous catalysis
isocyanides
multicomponent reactions
palladium
Physical Sciences
Science & Technology
multicomponent reactions
palladium
amidines
isocyanides
homogeneous catalysis
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Summary:Tin‐free three‐component coupling: Palladium‐catalyzed coupling between aryl or heteroaryl bromides, primary or secondary amines, and tert‐butyl isocyanide gives high yields of pharmaceutically interesting arylamidines [Eq. (1)]. dppf=1,1′‐bis(diphenylphosphanyl)ferrocene; R1/R2=Bu/H, Ph/H, −(CH2)4−.
Bibliography:istex:B647B7182536725B9DF945D58FC818E3427EFB10
ark:/67375/WNG-5WLLZWDR-8
ArticleID:ANIE4156
This research was supported by AstraZeneca plc.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20001117)39:22<4156::AID-ANIE4156>3.0.CO;2-B