The role of obesity duration on the association between obesity and risk of physical disability
Objective To relate measured obesity duration in mid‐life with subsequent incidence of physical disability over and above body mass index (BMI) attained. Methods Framingham Offspring Study is a longitudinal study that began in 1971. Examination 5 (1991‐1995; “baseline”) and disability onset ascertai...
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Published in | Obesity (Silver Spring, Md.) Vol. 23; no. 2; pp. 443 - 447 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.02.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Objective
To relate measured obesity duration in mid‐life with subsequent incidence of physical disability over and above body mass index (BMI) attained.
Methods
Framingham Offspring Study is a longitudinal study that began in 1971. Examination 5 (1991‐1995; “baseline”) and disability onset ascertained from examinations 6‐8 (2008) were used. About 2,095 disability‐free participants aged 45‐65 years at baseline were included. Obesity (BMI ≥ 30 kg/m2) duration was calculated between examination 1 and examination 5. Cox regression was used to analyze time to disability.
Results
204 participants developed disability (incidence rate = 7.9 per 1,000 person‐years). Obesity duration ranged from 0 to 22 years (mean of 2.0 years overall, 8.3 years for those with baseline obesity). Obesity duration increased risk of new disability (hazard ratio [HR] 1.07 per year of obesity; 95% confidence interval [CI] 1.05‐1.09). This association was attenuated on further adjustment for baseline BMI (HR 1.03; 95% CI 1.00‐1.06).
Conclusions
Being obese for longer during mid‐life increases the risk of later‐life disability over and above attained BMI. These results support the need for prevention of weight gain in young adults to avoid an increasing burden of physical disability in later life. |
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Bibliography: | EW, formulation of research question, design of protocol, data analysis, drafted manuscript, and responsible for manuscript submission and responding to reviewer comments; AP, ST, formulation of research question, design of protocol, interpretation, and commented on manuscript drafts; RW, design of protocol, interpretation, and commented on the final manuscript; KB, CS, AA, interpretation and commented on manuscript drafts. The authors declared no conflict of interest. Disclosure Funding agencies This work was supported by Monash University Australian Postgraduate Award and Baker IDI Bright Sparks Foundation Top‐up Award to EW; a VicHealth and National Health and Medical Research Council (NHMRC) Fellowship to AP; and a National Heart Foundation fellowship to KB. This work was also supported by funding from the Australian Research Council (Linkage Project Grant 12010041 & Discovery Grant 120103277) and NHMRC Project Grant (APP1044366). Author contributions ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1930-7381 1930-739X |
DOI: | 10.1002/oby.20936 |