Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis

• Published in: Interactive cardiovascular and thoracic surgery Vol. 9; no. 3; pp. 437 - 440
• Main Authors: Takagi, Hisato, Manabe, Hideaki, Kawai, Norikazu, Goto, Shin-nosuke, Umemoto, Takuya
• Format: Journal Article
• Language: English
• Published: England Eur Assoc Cardio Surg 01.09.2009
• Subjects: Aortic Aneurysm, Abdominal - enzymology; Aortic Aneurysm, Abdominal - mortality; Aortic Rupture - enzymology; Aortic Rupture - mortality; Biomarkers - blood; Evidence-Based Medicine; Humans; Matrix Metalloproteinase 9 - blood; Publication Bias; Up-Regulation
• ISSN: 1569-9293; 1569-9285
• DOI: 10.1510/icvts.2009.208835

Department of Cardiovascular Surgery, Shizuoka Medical Center, 762-1 Nagasawa, Shimizu-cho, Sunto-gun, Shizuoka 411-8611, Japan *Corresponding author. Tel.: +81 559752000; fax: +81 559752725. E-mail address : kfgth973{at}ybb.ne.jp (H. Takagi). To summarize the present evidence for an association between matrix metalloproteinase-9 (MMP-9) and abdominal aortic aneurysm (AAA) presence, we performed a meta-analysis of case-control studies that compared circulating MMP-9 concentrations between patients with AAA and subjects without AAA. MEDLINE database was searched to identify all case-control studies. For each study, data regarding serum or plasma MMP-9 concentrations in both the AAA and control groups were used to generate standardized mean differences (SMDs) and 95% confidence intervals (CIs). Study-specific estimates were combined using inverse variance-weighted average of logarithmic SMDs in both fixed- and random-effects models. Our search identified eight eligible studies including 580 patients with AAA and 258 subjects without AAA. Pooled analysis demonstrated significantly higher circulating MMP-9 concentrations in the AAA group than those in the control group in random-effect models (SMD, 0.70; 95% CI, 0.23–1.17; P =0.004). There was significant study heterogeneity of results ( P <0.00001) but no evidence of significant publication bias ( P =0.1376). We found that, based on a systematic review and meta-analysis, circulating MMP-9 concentrations are higher in patients with AAA than those in subjects without AAA. Higher circulating MMP-9 concentrations are associated with AAA presence. Key Words: Matrix metalloproteinase-9; Aortic aneurysm, abdomen; Biological markers