Palladium‐Catalyzed Annulation of Aryltriazoles and Arylisoxazoles with Alkynes

We developed herein a palladium‐catalyzed annulation of aryltriazoles and arylisoxazoles with internal alkynes via C−H bond activation process. 4,5‐disubstituted‐3H‐naphtho[1,2‐d][1,2,3]triazoles and 4,5‐disubstituted‐naphtho[2,1‐d]isoxazoles could be afforded in good yields, respectively. The start...

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Published inAdvanced synthesis & catalysis Vol. 361; no. 18; pp. 4386 - 4392
Main Authors Yuan, Hairui, Wang, Min, Xu, Zhenghu, Gao, Hongyin
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 17.09.2019
Wiley Subscription Services, Inc
Subjects
Alkynes
Annulation
Chemical reactions
Chemistry
Chemistry, Applied
Chemistry, Organic
Hydrogen bonds
Isoxazole
Naphthalene
Organic chemistry
Palladium
Physical Sciences
Polycylces
Science & Technology
Triazole
Triazoles
ROLLOVER
Triazole
CLICK CHEMISTRY
Isoxazole
Palladium
OXIDATIVE ANNULATION
ARYLATION SEQUENCE
INTERNAL ALKYNES
CLEAVAGE
C-H ACTIVATION
TRIAZOLES
1,2,3-TRIAZOLES
REGIOSELECTIVE SYNTHESIS
Polycylces
Annulation
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ISSN1615-4150
1615-4169
DOI10.1002/adsc.201900435

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Summary:We developed herein a palladium‐catalyzed annulation of aryltriazoles and arylisoxazoles with internal alkynes via C−H bond activation process. 4,5‐disubstituted‐3H‐naphtho[1,2‐d][1,2,3]triazoles and 4,5‐disubstituted‐naphtho[2,1‐d]isoxazoles could be afforded in good yields, respectively. The starting materials are readily available and the scope and applications of this transformation were explored. The reaction offers a practical approach to naphthalene fused heterocycles.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900435