Paclitaxel‐Loaded PLA/PEG/Magnetite Anticancer and Hyperthermic Agent Prepared From Materials Obtained by the Ugi's Multicomponent Reaction

In this study, Magnetic microspheres formed by Magnetite, Paclitaxel (PCT), poly(lactic acid) (PLA), and poly(ethylene glycol) (PEG) diblock copolymers material, synthesized by the Ugi four‐component condensation reaction (UFCC), are prepared by single emulsion and solvent evaporation procedure. Pre...

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Bibliographic Details
Published inMacromolecular symposia. Vol. 380; no. 1
Main Authors Peña Icart, Luis, Fernandes dos Santos, Edson, Agüero Luztonó, Lissette, Zaldívar Silva, Dionisio, Andrade, Leonardo, Lopes Dias, Marcos, Trambaioli da Rocha e Lima, Luis M., Gomes de Souza, Fernando
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.08.2018
Subjects
Anticancer properties
Antitumor activity
Cancer
Chemical synthesis
Condensates
Controlled release
copolymers poly(ethyleneglycol)‐poly(lactic acid)
Drug delivery
Drug delivery systems
Evaporation
High-performance liquid chromatography
Hyperthermia
hypethermic therapy
Intestine
Magnetic induction
magnetic microparticles
Magnetite
Microencapsulation
Microspheres
Paclitaxel
Polyethylene glycol
Polylactic acid
Ugi four component condensation
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Summary:In this study, Magnetic microspheres formed by Magnetite, Paclitaxel (PCT), poly(lactic acid) (PLA), and poly(ethylene glycol) (PEG) diblock copolymers material, synthesized by the Ugi four‐component condensation reaction (UFCC), are prepared by single emulsion and solvent evaporation procedure. Prepared PCT‐loaded magnetic microspheres (PCTMMS) are characterized by magnetic induction hyperthermia (MIH), SEM, and LDS techniques. Microencapsulation process yielded PCT encapsulation efficiency (Ee) between 70 and 80%, determined by HPLC analysis of the resulting supernatant after the microencapsulation process. A kinetic study of drug release in vitro using HPLC showed a sustained and controlled release of PCT. Also, the presence of an external magnetic field speeds up the kinetic release profile of PCT. Anticancer activity of release medium against intestine cancer cell line (Caco2) is determined using the cell viability assay. PCTMMSs are able to inhibit cancer cell growth and colony formation. The main contribution of these results is to propose a new application for UFCC in the preparation of one anticancer and hyperthermic drug delivery systems (DDS) able to improve the cancer treatment and even the welfare of the patients.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.201800094