The relationship between folic acid and nonalcoholic fatty liver disease

In recent years, the incidence of non‐alcoholic fatty liver disease (NAFLD) has been increasing, which has become an explosive interest because of the growing impact on world health. NAFLD is the hepatic manifestation of systemic metabolic syndrome (MS), and the umbrella term that comprises a contin...

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Published inClinical and translational discovery Vol. 4; no. 1
Main Authors Xu, Bing'er, Yang, Xinyu, Zhu, Xiaopeng, Liu, Qiling, Zhang, Yuying, Zhang, Miao, Fan, Chenmin, Ban, Xilei, Aikebaier, Guligeina, bian, Hua
Format Journal Article
LanguageEnglish
Published Birtinya John Wiley & Sons, Inc 01.02.2024
Wiley
Subjects
Carbon
Dehydrogenases
Diet
Dihydrofolate reductase
DNA methylation
Enzymes
Epigenetics
Fatty acids
Genes
Homeostasis
Lipids
Liver cancer
Liver diseases
Metabolism
Metabolites
Oxidative stress
Vitamin B
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Summary:In recent years, the incidence of non‐alcoholic fatty liver disease (NAFLD) has been increasing, which has become an explosive interest because of the growing impact on world health. NAFLD is the hepatic manifestation of systemic metabolic syndrome (MS), and the umbrella term that comprises a continuum of liver conditions, from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosis and hepatocellular carcinoma (HCC). currently, there is no pharmacological agent that is therapeutically approved for the treatment of this disease. Folic acid (FA) was one of a water‐soluble B vitamins, entirely absorbed from the diet. Numbers of clinical studies have confirmed that patients with NAFLD and insulin resistance are often accompanied by abnormal FA. We investigated the potential effects of FA on NAFLD through the metabolic pathways, DNA synthesis and methylation, oxidative stress in liver and intestinal flora. In addition, FA has an effect on HCC or other cancer. Therefore, FA might be a safe and economical potential treatment method for NAFLD. 1. The beneficial effects of FA on NAFLD might be the DNA methylation regulation of NAFL‐related genes. 2. FA may reduce inflammation and ER stress in the liver through direct or indirect effects. 3. FA may improve NAFLD by enhance the tight junction and reduce intestinal inflammation.
Bibliography:Bing'er Xu and Xinyu Yang contributed equally.
ISSN:2768-0622
2768-0622
DOI:10.1002/ctd2.274