Developmental Biology: Vasculogenesis is a Wreck Without RECK

The unique membrane-associated inhibitor of matrix metalloproteinases, RECK, is required for vascular maturation during embryogenesis. The phenotype of a loss of function mutation of RECK shows the importance of pericellular proteolysis in development.

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Bibliographic Details
Published inCurrent biology Vol. 12; no. 6; pp. R209 - R211
Main Authors Welm, Bryan, Mott, Joni, Werb, Zena
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 19.03.2002
Subjects
Amino Acid Sequence
Animals
Blood Vessels - embryology
Blood Vessels - metabolism
Endothelium, Vascular - growth & development
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
Glycoproteins - metabolism
GPI-Linked Proteins
Humans
Matrix Metalloproteinases - metabolism
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Molecular Sequence Data
Mutation
Sequence Homology, Amino Acid
Tissue Inhibitor of Metalloproteinase-2 - metabolism
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Summary:The unique membrane-associated inhibitor of matrix metalloproteinases, RECK, is required for vascular maturation during embryogenesis. The phenotype of a loss of function mutation of RECK shows the importance of pericellular proteolysis in development.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(02)00752-2