KF/clinoptilolite nanoparticles as a novel catalyst for the green synthesis of chromens using three component reactions of 4‐hydroxycoumarins: Study of antioxidant activity

• Published in: Journal of the Chinese Chemical Society (Taipei) Vol. 66; no. 10; pp. 1347 - 1355
• Main Authors: Sharifi, Samanehsadat, Maghsoudlou, Malek Taher, Hazeri, Nourallah, Rostami‐Charati, Faramarz
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.10.2019; Wiley; Wiley Subscription Services, Inc
• Subjects: aldehyde; Aldehydes; Antioxidants; Catalysts; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; chromenes; DPPH radical trapping; ferric ion; Ferric ions; Ketones; KF/clinoptilolite nanoparticles; Nanoparticles; Physical Sciences; Reaction time; Science & Technology; Substrates; Trapping; clinoptilolite nanoparticles; SOYBEAN OIL; DPPH radical trapping; aldehyde; ANTIHYPERTENSIVE ACTIVITY; ketones; APOPTOSIS INDUCERS; POTASSIUM FLUORIDE; BASE; MULTICOMPONENT REACTIONS; EFFICIENT CATALYST; chromenes; HETEROCYCLES; BIODIESEL; KF; ferric ion; SOLVENT-FREE SYNTHESIS
• ISSN: 0009-4536; 2192-6549
• DOI: 10.1002/jccs.201800282

In this research, the green synthesis of chromen derivatives in good yields is described via three‐component reactions of 4‐hydroxycumarine, aldehydes or ketones, and methyl ketones in the presence of KF/clinoptilolite nanoparticles (KF/CP‐NPs) under solvent‐free conditions at 50°C in low time. The present methodology suggests some advantages such as low reaction time, easy and simple procedure, green method, inexpensive catalyst, high yield of product, and existence of different substrates for performing these reactions. In addition, it should be mentioned that antioxidant activity was studied for some prepared compounds, such as 4a–4d, by DPPH radical trapping and reducing potential tests of ferric ion and then comparing results with TBHQ and BHT as synthetic antioxidants. In this study, compounds 4c was shown to have moderate DPPH radical trapping, and compounds 4b and 4d displayed good reducing power of ferric ion. In this research, green synthesis of chromen derivatives in good yields is described via three‐component reactions of 4‐hydroxycumarine, aldehydes or ketones, and methyl ketones in the presence of KF/clinoptilolite nanoparticles (KF/CP‐NPs) under solvent‐free conditions at 50°C in low time. The present methodology suggests some advantages, such as low reaction time, easy and simple procedure, green method, inexpensive catalyst, high yield of product, and existence of different substrates for performing these reactions. In addition, it should be mentioned that antioxidant activity was studied for some prepared compounds, such as 4a–4d, via the DPPH radical trapping and reducing potential tests of ferric ion and comparing results with TBHQ and BHT as synthetic antioxidants. In this study, compound 4c was shown to have moderate DPPH radical trapping, and compounds 4b and 4d displayed good reducing power of ferric ion.