Targeting the two-pore channel 2 in cancer progression and metastasis

The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels (TPCs), a group of recently identified Ca2+-channels,...

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Published inExploration of targeted anti-tumor therapy Vol. 3; no. 1; pp. 62 - 89
Main Authors Skelding, Kathryn A., Barry, Daniel L., Theron, Danielle Z., Lincz, Lisa F.
Format Journal Article
LanguageEnglish
Published Open Exploration 2022
Open Exploration Publishing Inc
Subjects
anti-cancer drugs
cancer
naringenin
Review
tetrandrine
tpcn2
two-pore channel 2
verapamil
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Summary:The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels (TPCs), a group of recently identified Ca2+-channels, located within the endolysosomal system. TPC2 has recently emerged as an intracellular ion channel of significant pathophysiological relevance, specifically in cancer, and interest in its role as an anti-cancer drug target has begun to be explored. Herein, an overview of the cancer-related functions of TPC2 and a discussion of its potential as a target for therapeutic intervention, including a summary of clinical trials examining the TPC2 inhibitors, naringenin, tetrandrine, and verapamil for the treatment of various cancers is provided.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2692-3114
2692-3114
DOI:10.37349/etat.2022.00072