Enantioselective Hydrogenation of Ketones using Different Metal Complexes with a Chiral PNP Pincer Ligand

The synthesis of different metal pincer complexes coordinating to the chiral PNP ligand bis(2‐((2R,5R)‐2,5‐dimethyl‐phospholanoethyl))amine is described in detail. The characterized complexes with Mn, Fe, Re and Ru as metal centers showed good activities regarding the reduction of several prochiral...

Full description

Saved in:
Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 361; no. 8; pp. 1913 - 1920
Main Authors Garbe, Marcel, Wei, Zhihong, Tannert, Bianca, Spannenberg, Anke, Jiao, Haijun, Bachmann, Stephan, Scalone, Michelangelo, Junge, Kathrin, Beller, Matthias
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 16.04.2019
Subjects
Aliphatic compounds
Asymmetric Catalysis
Asymmetric Hydrogenation
Chiral Alcohols
Chiral Pincer
Coordination compounds
Enantiomers
Iron
Ketones
Ligands
Manganese
Noble metals
Prochiral Ketones
Selectivity
Substrates
Online AccessGet full text

Cover

More Information
Summary:The synthesis of different metal pincer complexes coordinating to the chiral PNP ligand bis(2‐((2R,5R)‐2,5‐dimethyl‐phospholanoethyl))amine is described in detail. The characterized complexes with Mn, Fe, Re and Ru as metal centers showed good activities regarding the reduction of several prochiral ketones. Comparing these catalysts, the non‐noble metal complexes produced best selectivities not only for aromatic substrates, but also for different kinds of aliphatic ones leading to enantioselectivities up to 99% ee. Theoretical investigations elucidated the mechanism and rationalized the selectivity.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201801511