Liver Regeneration in Acute on Chronic Liver Failure

Liver regeneration is a multifaceted process by which the organ regains its original size and histologic organization. In recent decades, substantial advances have been made in our understanding of the mechanisms underlying regeneration following loss of hepatic mass. Liver regeneration in acute liv...

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Bibliographic Details
Published inClinics in liver disease Vol. 27; no. 3; p. 595
Main Authors Blake, Madelyn J, Steer, Clifford J
Format Journal Article
LanguageEnglish
Published United States 01.08.2023
Subjects
Acute-On-Chronic Liver Failure - therapy
Focal Nodular Hyperplasia
Humans
Liver Regeneration
MicroRNAs - genetics
microRNAs
Acute liver failure
Regeneration
Cytokines
Homeostasis
Acute on chronic liver failure
Partial hepatectomy
Growth factors
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Summary:Liver regeneration is a multifaceted process by which the organ regains its original size and histologic organization. In recent decades, substantial advances have been made in our understanding of the mechanisms underlying regeneration following loss of hepatic mass. Liver regeneration in acute liver failure possesses several classic pathways, while also exhibiting unique differences in key processes such as the roles of differentiated cells and stem cell analogs. Here we summarize these unique differences and new molecular mechanisms involving the gut-liver axis, immunomodulation, and microRNAs with an emphasis on applications to the patient population through stem cell therapies and prognostication.
ISSN:1557-8224
DOI:10.1016/j.cld.2023.03.005