Gene-environment interactions that influence CVD, lipid traits, obesity, diabetes, and hypertension appear to be able to influence gene therapy

• Published in: Molecular aspects of medicine Vol. 94; p. 101213
• Main Author: Dowaidar, Moataz
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2023
• Subjects: Cardiovascular Diseases - complications; Cardiovascular Diseases - genetics; Cardiovascular Diseases - therapy; CVD; Diabetes; Diabetes Mellitus - genetics; Diabetes Mellitus - therapy; Disease; Environment; Gene; Gene-Environment Interaction; Genetic; Humans; Hypertension; Hypertension - genetics; Hypertension - therapy; Lipids; Obesity; Obesity - complications; Obesity - genetics; Obesity - therapy; Risk Factors; Therapy; CVD; Hypertension; Therapy; Obesity; Gene; Disease; Genetic; Environment; Diabetes
• ISSN: 0098-2997; 1872-9452
• DOI: 10.1016/j.mam.2023.101213

Most mind boggling diseases are accepted to be impacted by both genetic and environmental elements. As of late, there has been a flood in the improvement of different methodologies, concentrate on plans, and measurable and logical techniques to examine gene-environment cooperations (G × Es) in enormous scope studies including human populaces. The many-sided exchange between genetic elements and environmental openings has long charmed the consideration of clinicians and researchers looking to grasp the complicated starting points of diseases. While single variables can add to disease, the blend of genetic variations and environmental openings frequently decides disease risk. The fundamental point of this paper is to talk about the Gene-Environment Associations That Impact CVD, Lipid Characteristics, Obesity, Diabetes, and Hypertension Have all the earmarks of being Ready to Impact Gene Therapy. This survey paper investigates the meaning of gene-environment collaborations (G × E) in disease advancement. The intricacy of genetic and environmental communications in disease causation is explained, underlining the multifactorial idea of many circumstances. The job of gene-environment cooperations in cardiovascular disease, lipid digestion, diabetes, obesity, and hypertension is investigated. This audit fixates on Gene by Environment (G × E) collaborations, investigating their importance in disease etiology.