DNA damage and hormone-related cancer: a repair pathway view

Abstract In this short review, we examine the overlap between genes known to be mutated in the germlines of individuals at risk of breast, ovarian and prostate cancers, and their positions in DNA damage repair pathways. Cancer risk mutations have been consistently reported in certain genes at the to...

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Bibliographic Details
Published inHuman molecular genetics Vol. 28; no. R2; pp. R180 - R186
Main Authors Pooley, Karen A, Dunning, Alison M
Format Journal Article
LanguageEnglish
Published England Oxford University Press 21.11.2019
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Summary:Abstract In this short review, we examine the overlap between genes known to be mutated in the germlines of individuals at risk of breast, ovarian and prostate cancers, and their positions in DNA damage repair pathways. Cancer risk mutations have been consistently reported in certain genes at the top of these pathways, but none have been reported in others. We consider whether some of these gene products are too crucial to life for mutations to be tolerated, whilst others, further down the pathways, are less essential.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddz206