Leishmania mexicana cell death achieved by Cleoserrata serrata (Jacq.) Iltis: Learning from Maya healers

Aerial parts of Cleoserrata serrata (Jacq.) Iltis are widely used in South-Central Mexico to treat wounds and bacterial skin infections and in Panama by Kuna, Ngöbe-Buglé, and Teribe Indians for tropical warm baths and by Kunas in the form of “Ina kuamakalet” for snakebites. To evaluate the effect o...

Full description

Saved in:
Bibliographic Details
Published inJournal of ethnopharmacology Vol. 211; pp. 180 - 187
Main Authors Alamilla-Fonseca, Lorena Noemi, Delgado-Domínguez, José, Zamora-Chimal, Jaime, Cervantes-Sarabia, Rocely Buenaventura, Jiménez-Arellanes, Adelina, Rivero-Cruz, José Fausto, Becker, Ingeborg
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 30.01.2018
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Aerial parts of Cleoserrata serrata (Jacq.) Iltis are widely used in South-Central Mexico to treat wounds and bacterial skin infections and in Panama by Kuna, Ngöbe-Buglé, and Teribe Indians for tropical warm baths and by Kunas in the form of “Ina kuamakalet” for snakebites. To evaluate the effect of Cleoserrata serrata extract on growth and viability of L. mexicana amastigotes and promastigotes in vitro, as well as on bacteria that usually co-infect skin ulcers. Cleoserrata serrata was collected in La Chontalpa, Tabasco, Mexico. The antiproliferative effect of the extract was tested on growth of Leishmania mexicana amastigotes and promastigotes in vitro, as well as on bacteria that usually co-infect skin ulcers. Our data show that Cleoserrata serrata significantly inhibits parasite growth (which was more important in infective amastigotes) and additionally inhibits growth of the co-infective bacteria Staphylococcus aureus and Pseudomonas aeruginosa. Confocal microscopy showed a leishmanicidal effect. We conclude that Cleoserrata serrata extract is potentially an optimal treatment alternative for patients with cutaneous leishmaniasis infected with Leishmania mexicana, since it controls both the parasite as well as bacterial co-infections. Furthermore, it can be applied topically. The precise metabolites responsible for the anti-Leishmania and anti-bacterial effects remain to be established. [Display omitted]
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2017.09.037