Nanoengineered silica: Properties, applications and toxicity

Silica nanoparticles are widely used for biomedical purposes, but also in cosmetic products, food, the car industry, paints, etc. Considering their mega production, one should not ignore their potential hazardous effects on humans, flora and fauna. Human exposure to nanosilica can occur unintentiona...

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Bibliographic Details
Published inFood and chemical toxicology Vol. 109; no. Pt 1; pp. 753 - 770
Main Authors Mebert, Andrea M., Baglole, Carolyn J., Desimone, Martin F., Maysinger, Dusica
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2017
Subjects
Animals
cAMP
Drug Delivery Systems - instrumentation
Epigenetics
HaCaT
Humans
Nanoengineered silica
Nanoparticles - chemistry
Nanoparticles - toxicity
Silicon Dioxide - chemistry
Silicon Dioxide - toxicity
SiNPs
Epigenetics
SiNPs
Nanoengineered silica
cAMP
HaCaT
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Summary:Silica nanoparticles are widely used for biomedical purposes, but also in cosmetic products, food, the car industry, paints, etc. Considering their mega production, one should not ignore their potential hazardous effects on humans, flora and fauna. Human exposure to nanosilica can occur unintentionally in daily life and in industrial settings. Here, we review the common methods of silica nanoparticle production and its applications in biomedical investigations and nanotoxicology. The use of silica nanoparticles in biomedicine is discussed in terms of drug delivery, their responsiveness to different stimuli, theranostic applications and their uses in the food and cosmetic industries. Advantages and limitations of silica nanoparticles are presented and the effects of these nanoparticles are discussed in relation to their route of entry and impact on biochemical and epigenetic processes in human and animal cells.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2017.05.054