Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development

Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system w...

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Bibliographic Details
Published inCurrent opinion in microbiology Vol. 46; pp. 116 - 122
Main Authors Kalel, Vishal C, Mäser, Pascal, Sattler, Michael, Erdmann, Ralf, Popowicz, Grzegorz M
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2018
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Summary:Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids’ glycosomal transport components as targets for new trypanocidal therapies.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2018.11.003