Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells

• Published in: Planta medica Vol. 67; no. 8; p. 750
• Main Authors: Cho, H, Jun, J Y, Song, E K, Kang, K H, Baek, H Y, Ko, Y S, Kim, Y C
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2001
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Carcinoma, Hepatocellular - drug therapy; Ficusin - chemistry; Ficusin - isolation & purification; Ficusin - pharmacology; Heterocyclic Compounds, 3-Ring - chemistry; Heterocyclic Compounds, 3-Ring - isolation & purification; Heterocyclic Compounds, 3-Ring - pharmacology; Humans; Phenols - chemistry; Phenols - isolation & purification; Phenols - pharmacology; Protective Agents; Psoralea - chemistry; Seeds - chemistry; Silymarin - pharmacology; Tacrine; Tumor Cells, Cultured
• ISSN: 0032-0943
• DOI: 10.1055/s-2001-18347

Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compounds 1 - 3 are 1.0, 47.0, 50.0 microg/ml, respectively. Silymarin as a positive control showed the EC(50) value with 5.0 microg/ml.