Vagus Nerve Stimulation for Treatment-Resistant Depression: a Case Series of Clinical Symptoms Associated with the End of Service Period
•There is a knowledge gap on VNS battery end of service (EOS) in depression.•New onset depressive symptoms and side effects are associated with VNS battery EOS.•Clinical symptoms could be more sensitive than the software to predict EOS.•Prospective studies on clinical symptoms during EOS are therefo...
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Published in | Journal of affective disorders Vol. 281; pp. 646 - 648 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
15.02.2021
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Subjects | |
Online Access | Get full text |
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Summary: | •There is a knowledge gap on VNS battery end of service (EOS) in depression.•New onset depressive symptoms and side effects are associated with VNS battery EOS.•Clinical symptoms could be more sensitive than the software to predict EOS.•Prospective studies on clinical symptoms during EOS are therefore needed.
This work describes the clinical symptoms associated with end of service (EOS) of the batteries of vagus nerve stimulation (VNS) generators in treatment-resistant depression (TRD). Because neurostimulator software may not provide reliable information on battery depletion, careful monitoring of clinical symptoms during the EOS period is an important concern in the follow-up of TRD patients treated with VNS therapy.
Twenty-six (26) patients were implanted and followed at the Centre Hospitalier de l'Université de Montréal. Fourteen (14) patients required battery replacement and we retrieved chart data up to 3 months before generator battery replacement.
Our study demonstrated there might be a decrease or increase in VNS associated physical side effects, and possibly an increase in depressive symptoms during EOS.
Our observations are limited by the retrospective nature of this small case series, and larger prospective studies evaluating both VNS side effects and depressive symptoms are therefore needed to further validate those findings.
Our study is the first to examine clinical symptoms associated with EOS of the batteries of VNS in TRD. |
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Bibliography: | SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
ISSN: | 0165-0327 1573-2517 |
DOI: | 10.1016/j.jad.2020.11.097 |