Modulatory Effect of Fenugreek Seed Mucilage and Spent Turmeric on Intestinal and Renal Disaccharidases in Streptozotocin Induced Diabetic Rats

• Published in: Plant foods for human nutrition (Dordrecht) Vol. 60; no. 2; pp. 87 - 91
• Main Authors: Suresh Kumar, G, Shetty, A.K, Salimath, P.V
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.06.2005
• Subjects: alpha-glucosidase; animal models; Animals; beta-galactosidase; Biological and medical sciences; Blood Glucose; Curcuma - chemistry; diabetes mellitus; Diabetes Mellitus, Experimental - enzymology; digestive enzymes; Disaccharidases - drug effects; Disaccharidases - metabolism; Feeding. Feeding behavior; Food industries; Fundamental and applied biological sciences. Psychology; Intestines - enzymology; Kidney - enzymology; Lactase - metabolism; Male; Random Allocation; Rats; Rats, Wistar; Sucrase - metabolism; sucrose alpha-glucosidase; Trigonella - chemistry; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Seeds; Rat; Specific activity; Reduction; Dicotyledones; Angiospermae; Fenugreek; Supplementation; Fenugreek seed mucilage; Enzyme; Lactase; Rodentia; Management; Feeding; Turmeric; Spent turmeric; Vertebrata; Mammalia; Leguminosae; Diet; Glycosidases; Hydrolases; Spermatophyta; Diabetes; O-Glycosidases; Disaccharidase; Trigonella foenum graecum
• ISSN: 0921-9668; 1573-9104
• DOI: 10.1007/s11130-005-5104-5

To elucidate the effect of feeding fenugreek seed mucilage and spent turmeric (10%) on disaccharidases activities, the specific activities of intestinal and renal disaccharidases viz., sucrase, maltase and lactase were measured in streptozotocin induced diabetic rats. Specific activities of intestinal disaccharidases were increased significantly during diabetes and amelioration of these activities during diabetes was clearly visible by supplementing fenugreek seed mucilage and spent turmeric in the diet. However during diabetes renal disaccharidases activities were significantly lower than those in the control rats. Fenugreek seed mucilage and spent turmeric supplementations were beneficial in alleviating the reduction in maltase activity during diabetes, however not much change in the activities of sucrase and lactase was observed upon feeding. This positive influence of feeding fenugreek seed mucilage and spent turmeric on intestinal and renal disaccharidases clearly indicates their beneficial role in the management of diabetes.