The neurology of lupus

•SLE can affect the nervous system, most frequently the brain, in up to 50% of patients and the first step in assessment should be to ensure a robust diagnosis of SLE.•Heterogeneity and lack of specificity of clinical neuropsychiatric (NP) events in SLE patients obliges clinicians to consider and ex...

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Bibliographic Details
Published inJournal of the neurological sciences Vol. 424; p. 117419
Main Authors Hanly, John G., Inanç, Murat
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.05.2021
Subjects
Humans
Lupus
Lupus Erythematosus, Systemic - diagnosis
Mental Disorders
Neurology
Neuropsychiatric
SLE
Lupus
Neurology
Neuropsychiatric
SLE
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Summary:•SLE can affect the nervous system, most frequently the brain, in up to 50% of patients and the first step in assessment should be to ensure a robust diagnosis of SLE.•Heterogeneity and lack of specificity of clinical neuropsychiatric (NP) events in SLE patients obliges clinicians to consider and exclude non-SLE causes.•Pathogenetic mechanisms for NPSLE includes vascular ischemia and inflammation mediated by autoantibodies, inflammatory mediators and microglial activation.•The clinical diagnosis of NPSLE may be may be supported by neuroimaging, autoimmune serologycerebrospinal fluid and neuropsychological testing.•Treatment of NPSLE includes anticoagulation, corticosteroids and immunosuppression in addition to symptomatic therapies and treatment of relevant comorbidities.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2021.117419