miRNAs orchestration of cardiovascular diseases – Particular emphasis on diagnosis, and progression

• Published in: Pathology, research and practice Vol. 248; p. 154613
• Main Authors: Elsakka, Elsayed G.E., Abulsoud, Ahmed I., El-Mahdy, Hesham A., Ismail, Ahmed, Elballal, Mohammed S., Mageed, Sherif S. Abdel, Khidr, Emad Gamil, Mohammed, Osama A., Sarhan, Omnia M., Elkhawaga, Samy Y., El-Husseiny, Ahmed A., Abdelmaksoud, Nourhan M., El-Demerdash, Aya A., Shahin, Reem K., Midan, Heba M., Elrebehy, Mahmoud A., Doghish, Ayman A., Doghish, Ahmed S.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.08.2023
• Subjects: Cardiovascular diseases; Diagnosis; Epigenetic regulation; MiRNA; Prognosis; Transcriptional regulation; eNOS; SPARC; FBXO28; PVO; Transcriptional regulation; I/R; PHB2; α-SMA; PI3K; Diagnosis; IL; AF; SMA; MiRNA; CVD; TAGLN2; VDAC1; CTEPH; ERK; lncRNA; RV; β-MHC; APAF-1; Notch 1; H/R; GATA-4; PDCD10; TNF α; EPCs; pri-miRNA; mRNAs; S100a8; XBP1; CF; SMAD3; Dicer; GRP78; ECM; CDK8; EFNA3; PTP1B; FasL; Nppa; PAH; FGFR2; CHF; BNP; PTEN; LV; HMGB1; Epigenetic regulation; ncRNA; NF-κB; SPRED1; UTR; ECs; pAF; mTOR; Rac1; RT-qPCR; EC; GPX4; CAF; VA; IPAH; MAPK; KLF15; SIRT1; DCM; pre-miRNA; ITGA5; Cardiovascular diseases; TLR4; Myh7; Bcl-2; ANP; Prognosis; miRNAs; PARP; NFAT; MACE; DROSHA; cFBs; PAK4; RISC; EVs; NAFT; VEGF; IDCM; TBX5; HIPK2; COL3A1; APC; PRC2; NOVA1; PH; BAX; HF; AHF
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2023.154613

MicroRNAs (miRNAs; miRs) are small non-coding ribonucleic acids sequences vital in regulating gene expression. They are significant in many biological and pathological processes and are even detectable in various body fluids such as serum, plasma, and urine. Research has demonstrated that the irregularity of miRNA in multiplying cardiac cells is linked to developmental deformities in the heart's structure. It has also shown that miRNAs are crucial in diagnosing and progressing several cardiovascular diseases (CVDs). The review covers the function of miRNAs in the pathophysiology of CVD. Additionally, the review provides an overview of the potential role of miRNAs as disease-specific diagnostic and prognostic biomarkers for human CVD, as well as their biological implications in CVD.