Ornithine Decarboxylase: A Promising and Exploratory Candidate Target for Natural Products in Cancer Chemoprevention

Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthesis, plays an important role in tumor progression, cell proliferation and differentiation. In recent years, ODC has been the subject of intense study among researchers, as a target for anti-cancer therapy and specific inhibito...

Full description

Saved in:
Bibliographic Details
Published inAsian Pacific journal of cancer prevention : APJCP Vol. 13; no. 5; pp. 2425 - 2427
Main Author Luqman, Suaib
Format Journal Article
LanguageEnglish
Published Thailand 01.01.2012
Subjects
Antineoplastic Agents - therapeutic use
Biological Products - therapeutic use
Enzyme Inhibitors - therapeutic use
Humans
Neoplasms - metabolism
Neoplasms - prevention & control
Ornithine Decarboxylase - metabolism
Ornithine Decarboxylase Inhibitors
Online AccessGet full text

Cover

More Information
Summary:Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthesis, plays an important role in tumor progression, cell proliferation and differentiation. In recent years, ODC has been the subject of intense study among researchers, as a target for anti-cancer therapy and specific inhibitory agents, have the potential to suppress carcinogenesis and find applications in clinical therapy. In particular, it is suggested that ODC is a promising candidate target for natural products in cancer chemoprevention. Future exploration of ornithine decarboxylase inhibitors present in nature may offer great hope for finding new cancer chemopreventive agents.
ISSN:1513-7368
2476-762X
DOI:10.7314/APJCP.2012.13.5.2425