Non-canonical actions of Nogo-A and its receptors

• Published in: Biochemical pharmacology Vol. 100; pp. 28 - 39
• Main Authors: Seiler, Stefanie, Di Santo, Stefano, Widmer, Hans Rudolf
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 15.01.2016
• Subjects: Animals; Brain - metabolism; Brain - pathology; Cell signaling; Distribution; Glioma - metabolism; Glioma - pathology; GPI-Linked Proteins - metabolism; Growth Inhibitors - metabolism; Humans; Multiple Sclerosis - metabolism; Multiple Sclerosis - pathology; Myelin Proteins - metabolism; Myelin Sheath - metabolism; Myelin Sheath - pathology; Neurites - metabolism; Neurites - pathology; Neurodegenerative diseases; Neurons - metabolism; Neurons - pathology; Nogo Proteins; Nogo-A; Nogo-receptor; Regenerative medicine; APP; GPI; OPC; Regenerative medicine; ALS; FGF2; PNS; Nogo-A; NgR1; Neurodegenerative diseases; Nogo-receptor; MS; EAE; SNpc; MVECs; IGF-1; LINGO-1; NGF; ER; RhoA; P75; RGC; NSCs; MAG; Distribution; GABA; Olig2; LTD; ROCK; CNS; LTP; PirB; RTN; EGFR; Cell signaling; TROY; OD; SVZ; CSF; HUVEC; S1PR2; MCAO; OMgp; MOD; BDNF; EGF; SOD; TrkB; PD; CRMP2; NPCs; Stat3; CA1 and CA3; DC; FGFR1
• ISSN: 0006-2952; 1873-2968
• DOI: 10.1016/j.bcp.2015.08.113

[Display omitted] Nogo-A is a myelin associated protein and one of the most potent neurite growth inhibitors in the central nervous system. Interference with Nogo-A signaling has thus been investigated as therapeutic target to promote functional recovery in CNS injuries. Still, the finding that Nogo-A presents a fairly ubiquitous expression in many types of neurons in different brain regions, in the eye and even in the inner ear suggests for further functions besides the neurite growth repression. Indeed, a growing number of studies identified a variety of functions including regulation of neuronal stem cells, modulation of microglial activity, inhibition of angiogenesis and interference with memory formation. Aim of the present commentary is to draw attention on these less well-known and sometimes controversial roles of Nogo-A. Furthermore, we are addressing the role of Nogo-A in neuropathological conditions such as ischemic stroke, schizophrenia and neurodegenerative diseases.