Current 25-hydroxyvitamin D assays: Do they pass the test?

• Published in: Clinica chimica acta Vol. 413; no. 13-14; pp. 1127 - 1134
• Main Authors: Ong, Lizhen, Saw, Sharon, Sahabdeen, Noorulhijjah Bte, Tey, Kiat Teng, Ho, Chung Shun, Sethi, Sunil Kumar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 11.07.2012
• Subjects: 25OHD testing; Accuracy; Chromatography, Liquid; Correlation; Humans; Immunoassay; Luminescent Measurements - standards; Precision; Quality Control; Radioimmunoassay; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Uncertainty; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - diagnosis; Correlation; Accuracy; 25OHD testing; Vitamin D; Precision

Vitamin D testing is becoming increasingly important with recent research demonstrating a correlation between vitamin D insufficiency and metabolic diseases, immunodeficiencies and other diseases. However, existing 25-hydroxyvitamin D (25OHD) assays lack comparability to the candidate reference meth...