Determining the effect of cadmium on embryogenesis in isolated administration and in combination with selenium and germanium citrates

• Published in: Medychni perspektyvy Vol. 25; no. 1; pp. 24 - 31
• Main Authors: Nefodov, O. O., Bilyshko, D. V., Kushnaryova, K. A., Shevchenko, O. S., Shatorna, V. F., Kefeli-Ianovska, O. I., Kozlovskaya, O. G.
• Format: Journal Article
• Language: English; Ukrainian
• Published: Dnipropetrovsk Dnipro State Medical University 01.01.2020
• Subjects: Cadmium; Chloride; embryogenesis in rat; Embryos; germanium citrate; Liver; Selenium; selenium citrate
• ISSN: 2307-0404
• DOI: 10.26641/2307-0404.2020.1.200395

Cadmium compounds found in biological systems form the ecological crisis of the planet. An urgent task for researchers is to determine the morphological changes that occur in the body under the action of cadmium compounds in both prenatal and postnatal ontogenesis. The article discusses the results of effect of intragastric administration of cadmium chloride/cadmium citrate in isolation and in combination with selenium and germanium citrates on embryogenesis of pregnant female rats. The aspect of the accumulation of cadmium salts in the liver of a 20-day-old embryo by polyelement analysis was also studied. The use of multielement analysis showed that the highest level of cadmium accumulation in the liver of embryos was found in the group of isolated administration of cadmium chloride. It has been proven that cadmium citrate accumulates in the liver to a lesser extent than cadmium chloride in the liver. The accumulation of cadmium chloride with selenium citrates, germanium in the groups of combined administration showed a decrease in the cadmium content in the liver of embryos. An analysis of the basic indicators of embryonic development of the experiment proved the embryotoxic effect of cadmium salts during enteral administration in modeling chronic cadmium intoxication, which is expressed in a decrease in the number of embryos in the litter and an increase in embryonic mortality in relation to the control group at all studied developmental periods. A decrease in embryonic mortality and an increase in the number of embryos at all stages of gestation in the experiment with the combined administration of cadmium salts with germanium citrate and selenium citrate indicates their antagonistic effect on cadmium embryotoxicity.