The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man

The Scribble, Par and Crumbs modules were originally identified in the vinegar (fruit) fly, Drosophila melanogaster, as being critical regulators of apico-basal cell polarity. In the present chapter we focus on the Scribble polarity module, composed of Scribble, discs large and lethal giant larvae....

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Bibliographic Details
Published inEssays in biochemistry Vol. 53; p. 141
Main Authors Elsum, Imogen, Yates, Laura, Humbert, Patrick O, Richardson, Helena E
Format Journal Article
LanguageEnglish
Published England 01.01.2012
Subjects
Actin Cytoskeleton
Animals
Cell Polarity - genetics
Cell Transformation, Neoplastic - genetics
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila melanogaster - physiology
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Growth and Development
Humans
Membrane Proteins - genetics
Membrane Proteins - metabolism
Protein Transport
Signal Transduction
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
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Summary:The Scribble, Par and Crumbs modules were originally identified in the vinegar (fruit) fly, Drosophila melanogaster, as being critical regulators of apico-basal cell polarity. In the present chapter we focus on the Scribble polarity module, composed of Scribble, discs large and lethal giant larvae. Since the discovery of the role of the Scribble polarity module in apico-basal cell polarity, these proteins have also been recognized as having important roles in other forms of polarity, as well as regulation of the actin cytoskeleton, cell signalling and vesicular trafficking. In addition to these physiological roles, an important role for polarity proteins in cancer progression has also been uncovered, with loss of polarity and tissue architecture being strongly correlated with metastatic disease.
ISSN:1744-1358
DOI:10.1042/bse0530141