Gastric cancer differentiation using Fourier transform near-infrared spectroscopy with unsupervised pattern recognition

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 101; pp. 127 - 131
• Main Authors: Yi, Wei-song, Cui, Dian-sheng, Li, Zhi, Wu, Lan-lan, Shen, Ai-guo, Hu, Ji-ming
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.01.2013
• Subjects: Adult; Aged; Cluster Analysis; Differentiation; Female; Fourier transform near-infrared spectroscopy; Gastric cancer; Humans; Male; Middle Aged; Principal Component Analysis; Sensitivity and Specificity; Spectroscopy, Fourier Transform Infrared - methods; Stomach - chemistry; Stomach - pathology; Stomach Neoplasms - chemistry; Stomach Neoplasms - diagnosis; Stomach Neoplasms - pathology; Unsupervised pattern recognition; Fourier transform near-infrared spectroscopy; Differentiation; Gastric cancer; Unsupervised pattern recognition
• ISSN: 1386-1425; 1873-3557
• DOI: 10.1016/j.saa.2012.09.037

[Display omitted] ► Major spectral differences were observed in three regions. ► Unsupervised pattern recognition techniques (PCA and CA) were used. ► The sensitivity, specificity and accuracy were 100%, 68.2% and 81.1%, respectively. The manuscript has investigated the application of near-infrared (NIR) spectroscopy for differentiation gastric cancer. The 90 spectra from cancerous and normal tissues were collected from a total of 30 surgical specimens using Fourier transform near-infrared spectroscopy (FT-NIR) equipped with a fiber-optic probe. Major spectral differences were observed in the CH-stretching second overtone (9000–7000cm−1), CH-stretching first overtone (6000–5200cm−1), and CH-stretching combination (4500–4000cm−1) regions. By use of unsupervised pattern recognition, such as principal component analysis (PCA) and cluster analysis (CA), all spectra were classified into cancerous and normal tissue groups with accuracy up to 81.1%. The sensitivity and specificity was 100% and 68.2%, respectively. These present results indicate that CH-stretching first, combination band and second overtone regions can serve as diagnostic markers for gastric cancer.