Synthesis of optically active tertiary silanes via Pd-catalyzed enantioselective arylation of secondary silanes

We herein describe the development of an efficient enantioselective catalytic system that promotes the arylation of secondary silanes. Our method involves treatment of secondary silanes and aryl iodides with a Pd-2(dba)(3)-asymmetric phosphoramidite ligand system to afford optically active tertiary...

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Published inChemical communications (Cambridge, England) Vol. 48; no. 94; pp. 11564 - 11566
Main Authors Kurihara, Yu, Nishikawa, Michihiro, Yamanoi, Yoshinori, Nishihara, Hiroshi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2012
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
CHIRAL SILICON GROUPS
ASYMMETRIC-SYNTHESIS
ABSOLUTE-CONFIGURATION
HYDROSILANES
ARYL HALIDES
ORGANIC HALIDES
CARBENOID INSERTION
AROMATIC-COMPOUNDS
ORGANOSILICON COMPOUNDS
SI-H BOND
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Summary:We herein describe the development of an efficient enantioselective catalytic system that promotes the arylation of secondary silanes. Our method involves treatment of secondary silanes and aryl iodides with a Pd-2(dba)(3)-asymmetric phosphoramidite ligand system to afford optically active tertiary silanes with good enantioselectivities.
Bibliography:KAKEN
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc36238d