A Pd-catalyzed, boron ester-mediated, reductive cross-coupling of two aryl halides to synthesize tricyclic biaryls

Tricyclic biaryls are important scaffold structures in many natural products and lead compounds in drug discovery. The formation of a biaryl unit is often the key step for the synthesis of tricyclic biaryls. Despite significant progress toward the synthesis of biaryl compounds in recent years, the d...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 15; no. 27; pp. 5790 - 5796
Main Authors Chen, Zhilong, Wang, Xiaodong
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.07.2017
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PHENANTHRIDINONE DERIVATIVES
ACID
SCOPE
AMARYLLIDACEAE
CYCLIZATION
ACCESS
ALKALOIDS
Online AccessGet full text

Cover

More Information
Summary:Tricyclic biaryls are important scaffold structures in many natural products and lead compounds in drug discovery. The formation of a biaryl unit is often the key step for the synthesis of tricyclic biaryls. Despite significant progress toward the synthesis of biaryl compounds in recent years, the direct cross-coupling of two different aryl halides is still challenging and robust methods are lacking. Herein we report a direct cross-coupling of two different aryl halides in the presence of a palladium catalyst and boron ester, which provides a new and useful complementary method to synthesize tricyclic biaryls.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01237c