Human platelet antigens are associated with febrile non-hemolytic transfusion reactions

• Published in: Clinica chimica acta Vol. 474; pp. 120 - 123
• Main Authors: Chen, Ding-Ping, Wen, Ying-hao, Lu, Jang-Jih, Tseng, Ching-Ping, Chen, Wan-Ling, Chang, Su-Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: Antigens, Human Platelet - genetics; Febrile non-hemolytic transfusion reaction (FNHTR); Fever - complications; Genotype; Human platelet antigen (HPA); Humans; Leukocyte-poor red blood cell (LPR); Sequence specific primer-polymerase chain reaction (SSP-PCR); Transfusion Reaction - complications; Transfusion Reaction - genetics; Human platelet antigen (HPA); Febrile non-hemolytic transfusion reaction (FNHTR); Leukocyte-poor red blood cell (LPR); Sequence specific primer-polymerase chain reaction (SSP-PCR)
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2017.09.010

Febrile non-hemolytic transfusion reaction (FNHTR) is the most common type of transfusion reactions, and it could be reduced by transfusing patients with leukocyte-poor blood products. However, FNHTR still occur in certain patients transfused with leukocyte-poor red blood cell (LPR) products. It is examined whether human platelet antigen (HPA) could be a potential membrane antigen that plays a role in FNHTR. A total of 120 inpatient subjects who transfused with LPR (60 in FNHTR group, 60 in control group) were typed for HPA-2, HPA-3, and HPA-15 using sequence specific primer-polymerase chain reaction (SSP-PCR) and electrophoresis. HPA-2 unmatched rate between donors and patients in FNHTR group was 18%, and only 3% unmatched rate was observed in control group (p=0.0082). FNHTR group was further classified according to the imputability. There was a significant difference (p=0.0041) between FNHTR (probable imputability, infection) group and control group, and more significant difference (p=0.0008) was seen between FNHTR (probable imputability, febrile neutropenia) group and control group. Those results indicated that HPA-2 might play roles on inducing FNHTR in patients suffering from infectious diseases and febrile neutropenia. HPA-2 genotyping between donors and recipients might be worth integrating in pre-transfusion testing to increase transfusion safety. •The human platelet antigen (HPA) could be a potential membrane antigen that plays a role in FNHTR.•FNHTR may occur through the HPA-2 antigen, especially in recipients with infectious disease or febrile neutropenia.•HPA-2 genotyping between donors and recipients might be worth integrating in pre-transfusion testing to increase transfusion safety.