Identification of a linear IgE inducing epitope on the SmATPDase1 surface

The Immunoglobulin E （IgE） response to Schistosoma mansoni con- stitutes a relevant host defense mechanism and is associated with resistance to reinfection and parasite expulsion [1]. Intriguingly, the IgE response raised against worms resembles an allergic reaction, with both being characterized by...

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Published inActa biochimica et biophysica Sinica Vol. 49; no. 6; pp. 564 - 566
Main Authors Braga Emídio, Nayara, Antonia do Nascimento Gusmão, Michelia, Castro Borges, William, Ryuichi Nakaie, Clovis, Gomes Vasconcelos, Eveline, Faria Pinto, Priscila de
Format Journal Article
LanguageEnglish
Published China 01.06.2017
Subjects
Amino Acid Sequence
Animals
Apyrase - genetics
Apyrase - immunology
Cross Reactions - immunology
Epitopes - immunology
Host-Parasite Interactions - immunology
Immunoglobulin E - blood
Immunoglobulin E - immunology
Mice, Inbred BALB C
Peptides - genetics
Peptides - immunology
Schistosoma mansoni - enzymology
Schistosoma mansoni - genetics
Schistosoma mansoni - immunology
Schistosomiasis mansoni - blood
Schistosomiasis mansoni - immunology
Schistosomiasis mansoni - parasitology
Sequence Homology, Amino Acid
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Summary:The Immunoglobulin E （IgE） response to Schistosoma mansoni con- stitutes a relevant host defense mechanism and is associated with resistance to reinfection and parasite expulsion [1]. Intriguingly, the IgE response raised against worms resembles an allergic reaction, with both being characterized by an intense Th2 response and increased levels of IgE antibodies and IL-4, IL-5, and IL-13 cyto- kines [2]. There is strong evidence that this similarity does not occur by chance and that the allergic response might have evolved as a defense against metazoan parasites [3,4],
Bibliography:31-1940/Q
The Immunoglobulin E （IgE） response to Schistosoma mansoni con- stitutes a relevant host defense mechanism and is associated with resistance to reinfection and parasite expulsion [1]. Intriguingly, the IgE response raised against worms resembles an allergic reaction, with both being characterized by an intense Th2 response and increased levels of IgE antibodies and IL-4, IL-5, and IL-13 cyto- kines [2]. There is strong evidence that this similarity does not occur by chance and that the allergic response might have evolved as a defense against metazoan parasites [3,4]
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ISSN:1672-9145
1745-7270
DOI:10.1093/abbs/gmx031