Chronic omeprazole use in the elderly is associated with decreased risk of dementia and cognitive decline

The association between proton pump inhibitor (PPI) use and increased risk of dementia is controversial. Investigating this issue in a large population of community-dwelling elders. Our database was retrospectively searched for all community-dwelling patients aged ≥65 years who newly diagnosed with...

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Published inDigestive and liver disease Vol. 54; no. 5; pp. 622 - 628
Main Authors Weiss, Avraham, Gingold-Belfer, Rachel, Boltin, Doron, Beloosesky, Yichayaou, Koren-Morag, Nira, Meyerovitch, Joseph, Sharon, Eran, Schmilovitz-Weiss, Hemda
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.05.2022
Subjects
Aged
Cognitive decline
Cognitive Dysfunction - epidemiology
DCD
Dementia
Dementia - epidemiology
Humans
Omeprazole - adverse effects
PPI
Proton Pump Inhibitors - adverse effects
Retrospective Studies
Risk Factors
Cognitive decline
PPI
DCD
Dementia
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Summary:The association between proton pump inhibitor (PPI) use and increased risk of dementia is controversial. Investigating this issue in a large population of community-dwelling elders. Our database was retrospectively searched for all community-dwelling patients aged ≥65 years who newly diagnosed with dementia/cognitive decline (DCD) between January 2002 - December 2012. Receiving ≥11 prescriptions of PPIs/year was categorized as PPI users. Clinical data were collected from the medical files. Risk of DCD in PPI users was analyzed by Cox regression models. Included 48,632 elders of whom 8,848 were diagnosed with DCD (18.2%). PPI use was documented in 10,507, of whom 1,959 were subsequently diagnosed with DCD (18.6%). Among 38,125 non-PPI users, 6,889 (18.1%) were diagnosed with DCD. The hazard ratio for occurrence of DCD in PPI users compared to non-users was 0.85 (95% CI: 0.81–0.89, P <0.001) in an un-adjusted Cox regression model and 0.83 in a Cox regression model adjusted for age and sex (95% CI: 0.79–0.87, P <0.001). Multivariate Cox regression accounting for background diseases, marital status, and socioeconomic state yielded a hazard ratio of 0.77 (95% CI: 0.73–0.81, P <0.001). PPI use wasn't associated with DCD development in chronic PPI users.
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2021.11.018