Stability of granisetron hydrochloride in an extemporaneously prepared oral liquid

• Published in: American journal of health-system pharmacy Vol. 54; no. 12; p. 1404
• Main Authors: Quercia, R A, Zhang, J, Fan, C, Chow, M S
• Format: Journal Article
• Language: English
• Published: England 15.06.1997
• Subjects: Chromatography, High Pressure Liquid; Drug Compounding; Drug Stability; Granisetron - chemistry; Hydrogen-Ion Concentration; Serotonin Antagonists - chemistry; Time Factors
• ISSN: 1079-2082
• DOI: 10.1093/ajhp/54.12.1404

The stability of granisetron 0.2 mg/mL (as the hydrochloride salt) in an extemporaneously prepared oral liquid was studied. Twelve 1-mg granisetron tablets were pulverized and suspended in 30 mL of distilled water. This mixture was then diluted with cherry syrup to produce a 60-mL oral liquid with a granisetron concentration of 0.2 mg/mL. Half of the preparation was stored at 5 degrees C, and half was stored at 24 degrees C. Samples were taken on days 0, 1, 2, 3, 4, 6, 8, 10, 12, and 14 and assayed by high-performance liquid chromatography. There was no change in the liquid's color, consistency, or pH, and the concentrations of granisetron ranged from 97% to 104% of initial concentration during the 14 days at 5 and 24 degrees C. Granisetron 0.2 mg/mL (as the hydrochloride salt) in an extemporaneously prepared oral liquid was stable for up to 14 days.