Cardioactive diterpenoids from the roots of Salvia amplexicaulis

Five diterpenoids, three steroids, four triterpenoids and one flavonoid were isolated from the roots of Salvia amplexicaulis Lam. (Lamiaceae). Structures of these compounds were elucidated by spectroscopic analysis. The crude extract and the pure compounds were tested for cardiovascular parameters u...

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Bibliographic Details
Published inPlanta medica Vol. 67; no. 8; p. 761
Main Authors Kolak, U, Ari, S, Birman, H, Hasançebi, S, Ulubelen, A
Format Journal Article
LanguageEnglish
Published Germany 01.11.2001
Subjects
Animals
Blood Pressure - drug effects
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - therapeutic use
Heart Rate - drug effects
Male
Molecular Structure
Phytotherapy
Plant Preparations - therapeutic use
Plant Roots - chemistry
Rats
Rats, Wistar
Salvia - chemistry
Vasoconstrictor Agents - chemistry
Vasoconstrictor Agents - isolation & purification
Vasoconstrictor Agents - therapeutic use
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Summary:Five diterpenoids, three steroids, four triterpenoids and one flavonoid were isolated from the roots of Salvia amplexicaulis Lam. (Lamiaceae). Structures of these compounds were elucidated by spectroscopic analysis. The crude extract and the pure compounds were tested for cardiovascular parameters using Wistar Albino rats. The crude extract, and 7-oxo-abieta-9,12,14-triene, ferruginol, stigmast-4-en-3-one showed a vasodepressor effect.
ISSN:0032-0943
DOI:10.1055/s-2001-18359