A self-assembled conformational switch: a host-guest stabilized triple stem molecular beacon via a photoactivated and thermal regeneration mode

We present a novel strategy for construction of a conformational switch of a molecular beacon based on the combination of nucleic acid (DNA) self-assembly and reversible host-guest inclusion interaction. With the functionalized probe, the nucleic acid hybridization process can be easily controlled w...

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Published inChemical communications (Cambridge, England) Vol. 50; no. 58; pp. 7803 - 7805
Main Authors He, Leiliang, Yang, Xiaohai, Wang, Kemin, Wang, Qing, Zhao, Fang, Huang, Jin, Liu, Jianbo
Format Journal Article
LanguageEnglish
Published England 01.01.2014
Subjects
DNA - chemistry
Nucleic Acid Conformation
Nucleic Acid Hybridization
Ultraviolet Rays
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Summary:We present a novel strategy for construction of a conformational switch of a molecular beacon based on the combination of nucleic acid (DNA) self-assembly and reversible host-guest inclusion interaction. With the functionalized probe, the nucleic acid hybridization process can be easily controlled with a photoactivated and thermal regeneration mode.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc01651c